Database

Data containing approximately 12,000,000 birth records were obtained from the United States Natality database for the years 2014 to 2016. In the United States, state laws require birth certificates to be completed for all births, and federal law mandates national collection and publication of births and other vital statistics data. The National Vital Statistics System, the federal compilation of these data, is the result of the cooperation between the National Center for Health Statistics (NCHS) and the states to provide access to statistical information from birth certificates. This study was evaluated by the Texas A&M Institutional Review Board (IRB) and determined to be exempt from IRB review.

1200만건의 출산사례 조사 간드앗!

When comparing the final CAR models with more traditional models, all models showed strong effects of maternal age on both Down syndrome and other Chromosomal disorders (Fig. 3a and c). The linear model did not fit the other 3 models well. The curvilinear model was very similar to the CAR model and 5-year age category model up to age 45, where the CAR model and 5-year age category model both produced an inflection point. In modeling paternal effects, all models showed agreement that the effect of increasing age is related to a decrease in the birth prevalence of Down syndrome (Fig. 3b and d).

모든 모델은 다운 증후군과 다른 염색체 장애 모두에 대해 산모의 연령이 강한 영향을 미치는 것으로 나타났고, 분석에 실시한 4가지 모델 중 어느 것도 다른 염색체 질환의 부계 연령 및 출생 유병률과의 연관성을 보여주지 않았음 ㅋㅋ

Conclusions