Ovarian aging is a natural and physiological aging process characterized by loss of quantity and quality of oocyte or follicular pool. As it is generally accepted that women are born with a finite follicle pool that will go through constant decline without renewing, which, together with decreased oocyte quality, makes a severe situation for women who is of advanced age but desperate for a healthy baby. The aim of our review was to investigate mechanisms leading to ovarian aging by discussing both extra- and intra- ovarian factors and to identify genetic characteristics of ovarian aging. The mechanisms were identified as both extra-ovarian alternation of hypothalamic–pituitary-ovarian axis and intra-ovarian alternation of ovary itself, including telomere, mitochondria, oxidative stress, DNA damage, protein homeostasis, aneuploidy, apoptosis and autophagy. Moreover, here we reviewed related Genome-wide association studies (GWAS studies) from 2009 to 2021 and next generation sequencing (NGS) studies of primary ovarian insufficiency (POI) in order to describe genetic characteristics of ovarian aging. It is reasonable to wish more reliable anti-aging interventions for ovarian aging as the exploration of mechanisms and genetics being progressing.

ovarianresearch.biomedcentral.com

Having children may take a biological toll on the body, according to the latest research.

time.com

A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accelerating biological aging. Supporting this prediction are findings that high fertility among women predicts shorter lifespan and poorer health later in li …

pubmed.ncbi.nlm.nih.gov

몇 년 전만해도 이 정도까지는 아니었는데, 갈수록 남자들이 여자들에게 나이, 노산 가지고 결혼 빨리해라고 난리치는 경우가 많아지는걸 느껴나는 여기에 결정사 유투버들이 큰 역할을 했다고 봐여자는 나이가 혼수다, 30넘어가면 급하다, 35년 노산이다 등등의 수면 밑에 있던 주제를 공공연히 꺼내서 여자를 후려치고 남자 기를 세워주며 결정사로 마음이 급해진 2030여자와 기세등등해진 3040남자를 영입하는데 성공했어그럼 뭐해이미 서로 너무 싫어하는 사...

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